Release Drug Delivery from Hydrogels
The objective of this project is to introduce students to
the concepts of diffusion, polymers and polymerization reactions,
and enzyme mediated reactions by designing and testing a
controlled release drug delivery system. These types of
systems are also referred to as localized drug delivery
because an implant that releases drugs is placed directly
into diseased tissue. Here, we use gelatin as a drug delivery
vehicle and food dye as a model drug. Physiological conditions
are simulated by placing a cube of the drug delivery system
into a test tube with varying ionic and enzymatic conditions.
The release of the food dye into the surrounding aqueous
environment is measured using a spectrophotomer.
was developed by Keith Neeves, a graduate student in the
School of Chemical and Biomolecular Engineering at Cornell
University. The curriculum was piloted and refined in Patricia
Carroll’s (Newark Valley High School) and Sarah Brumberg’s
(Lehman Alternative Community School) chemistry classes.